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Metabolic stress, calcium dysregulation and neuroinflammation mediated by glial cells like astrocytes and microglia further exacerbates RGC loss ( In many eye diseases, oxidative stress and mitochondrial dysfunction are key contributors to RGC degeneration

[DOI] [PMC free article] [PubMed] [Google Scholar] 20.Schafer G

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In fact, the studies reported that the study design and protocol had been designed by Novo Nordisk, but with the caveat that the study implementation and analysis of the results had been performed by independent researchers to mitigate the risk of funding bias