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Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1.8 million participants

Participants with obesity and knee osteoarthritis experienced average weight loss of 71.2 pounds alongside substantial relief from osteoarthritis pain

It is important to note that patients with a history of major depression were actually excluded from the phase 3 randomized controlled trials (RCTs) of these medications 10,11,12,13,14,15,21,22,23

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Prioritize sleep and stress regulation, and keep hydration and fiber consistent