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Description
Semaglutide is a GLP-1R single agonist, similar to tirzepatide, that significantly improves hyperglycemia and obesity and has been approved by the FDA in 2021 as a weight loss drug for chronic weight management [18]

But as far as I can tell, Amgen appears to have launched the product exclusively with Optum Rx

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Thus, clinical trials are needed to establish the benefits/risk profile in HF, considering that no properly designed, HF-specific randomised clinical trials have been completed with GLP-1 RAs in any of the HF phenotypes

It can affect patients both on a psychological and physical level, with overweight and obese people found to be at risk for diabetes, cardiovascular disease, cancer, and premature death [2]

Prostaglandins from cytosolic phospholipase A2/Cyclooxygenase-1 pathway and mitogen-activated protein kinases regulate gene expression in candida albicans-infected macrophages
