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Majeski JA, Upshur JK
Beraldo JI, Benetti A, Borges-Jnior FA, et al
Lancet 2007;370:1687-97.ArticlePubMed 791
In addition, small molecule positive allosteric modulators (PAMs) offer the potential for differentiation based on efficacy or safety profile
have heart failure or other heart problems
Where that runway ultimately leads will depend on evidence that is still being gathered, in trials that are still running, for outcomes that remain, for now, unmeasured.
