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Histological and Histopathological Evaluation of the Testis (Cache River Press, 1993)

Nat Rev Mol Cell Biol 17, 280292 (2016)

Specifically, intra-articular injection or systemic administration of specific ferroptosis inhibitors such as ferrostatin-1, or pharmacologically for example, using natural products or genetically for example, using overexpression vectors upregulating GPX4 expression, activating SLC7A11, or the key transcription factor Nrf2, can, to varying degrees, restore cartilage morphology, reduce chondrocyte death, and significantly lower the expression levels of ECM degradation markers in OA animal models

Despite extensive studies for the last 40 years, its regulation remains elusive 9,10

S.Ribeiro-AlvesM.et al

[DOI] [PubMed] [Google Scholar] 11.He XG, Lin LZ, Lian LZ