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Description

Robb, M

Clinical translation requires human CSF pharmacokinetic assays to prove BBB bypass, a rigorous dose-escalation Phase I trial to establish a safe human NOAEL for chronic dosing, and an RCT utilizing precise neurocognitive testing (e.g., MoCA) to confirm that murine transcriptomic shifts yield functional neuroprotection in humans

This includes nitrous oxide, proton-pump inhibitors, and metformin

Emerging small molecule approaches to enhance the antimyeloma benefit of proteasome inhibitors

Cantata: Randomized, international, double-blind study of cb-839 plus cabozantinib versus cabozantinib plus placebo in patients with metastatic renal cell carcinoma