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And stopping is far more common than the marketing suggests: one large 2025 analysis found that most people who start a GLP-1 for weight loss stop within two years

However, this event was associated with the concurrent use of ondansetron (an anti-nausea medication), not directly attributable to retatrutide itself

Since then, the evolution of GLP-1 receptor agonists has progressed from initial short-duration agents like exenatide, to intermediate-duration formulations such as liraglutide, and further to advanced long-acting options including dulaglutide and semaglutide (The two products received approval for marketing in the U.S

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