glp 1 and blood pressure Effects of tirzepatide, a dual GIP GLP-1 receptor agonist, on pressure, cardiac function, and sympathetic nervous system in stroke-prone spontaneously hypertensive rats Potential Use of GLP-1 and

Indianapolis, IN: Eli Lilly and Company

however, they act on different target organs and thus exert distinct physiological/pharmacologic effects

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These effects result in very significant weight loss (15-20% of initial body weight), i.e., of the same order of magnitude as that obtained by bariatric surgery

A recent trial on the treatment effect of semaglutide in people with obesity reported the significant effects of the long-acting GLP-1RA semaglutide on body weight and related phenotypes (169)

Considering the reported CV findings, cardiologists are qualified to take the lead in adopting CV risk mitigations strategies as a part of comprehensive management strategies in collaboration with endocrinologists/diabetologists