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Ongoing innovations aim to improve delivery systems, enhance potency and develop combination therapies to further optimize outcomes[16]

the extent of this brain penetration, however, is under debate and has been suggested to cover only the hypothalamus and hindbrain (140) or extend to many other populations including those found deep in the brain, for example in the hippocampus or NAc (27, 141, 142)

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However, it was not derived from patient focus groups nor was it initially designed to quantify pain, which has limited its application in some settings