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Given the established clinical use of GLP-1RAs for the treatment of T2DM, preclinical and clinical research was centered largely around DR, which suggested the neuropathologic protective effects of GLP-1 are due to downregulation of NF-B, proinflammatory cytokines such as TNF-alpha and IL-1beta, and VEGF

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doi:10.1124/jpet.111.186866 107

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For many, the answer is yes

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10.1002/(SICI)1096-9861(19990111)403:2 3.0.CO;2-5 [DOI] [PubMed] [Google Scholar] MietlickiBaase, E

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Their involvement ensures clients maintain a balanced diet rich in essential nutrients despite reduced caloric intake due to appetite suppression

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The white adipocyte hormone leptin[48] and pancreatic hormone insulin are the two major afferents governing long-term energy balance and act primarily as anorexigens

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