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Long-term use has been shown to reduce the risk of major cardiovascular events by 14%, all-cause mortality by 12%, and hospitalizations for heart failure by 11%

For pharmaceutical companies developing the next generation of GLP-1 therapies, choosing the right partners for both packaging and drug delivery may become just as important as choosing the right drug formulation

In the past ten years, a series of Phase III trials showed that the synthetic GLP-1/GIP agonists are effective in lowering blood sugar in type 2 diabetic subjects who were both treatment-nave or on typical first-line therapies such as metformin and insulin

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Consistent with these data, central administration of the GLP-1R agonists liraglutide and exendin-4 increases energy expenditure and BAT thermogenesis through mechanisms that include AMPK signaling in the mediobasal hypothalamus [666]
