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4.1.2 Limitations and research bottlenecks A major challenge in current research is the difficulty of decoupling the mediating effect of weight loss from the drugs direct pharmacological actions

Patients should be advised to: Rotate injection sites to prevent lipohypertrophy (lumps under the skin) Store unused pens in the refrigerator (28C)

doi: 10.3390/ijms241311162

Sci Rep 15 , 24103 (2025)

( 3.3 Development of unimolecular agents targeting both GIPR and GLP-1R The anti-obesity effects of GIPR antagonism antibody, both alone and in combination with GLP-1RAs, have been demonstrated in preclinical models of mice and monkeys (68, 73)