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This has led to multi-hormonal agents that act simultaneously on glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), glucagon, amylin and/or peptide YY (PYY), better replicating the physiological and coordinated post-prandial response

FDA approval of metformin for diabetes does not mean FDA approval for longevity use - those are distinct regulatory determinations, and the longevity indication is off-label

GLP-1 medications may not be appropriate for some patients

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