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Description

The GLP-1 receptor system is known to be expressed in areas of the brain involved in mood regulation, reward processing, and appetite control, including the hypothalamus and limbic system

Glucagon was traditionally considered counterproductive for weight management because it raises blood sugar

The labeled cRNAs were hybridized onto the Whole Mouse Genome Oligo Microarray (4x44K, Agilent Technologies)

A study published in the New England Journal of Medicine showed that one third of participants lost at least 20% of their weight

Keywords: GLP-1 receptor agonists, Neuroprotection, Synaptic plasticity, Central nervous system, Neurodegenerative diseases Graphical abstract Introduction GLP-1 receptor agonists (GLP-1RAs) are well-established treatments for type 2 diabetes mellitus (T2DM) and obesity, providing effective glycemic control, weight loss, and cardiovascular benefits [[1], [2], [3]]