negative effects of glp 1 drugs Struggling with GLP-1 therapy side effects? You're not alone. This Clinician Guide: Managing Common GLP-1 Receptor Agonist Side provides practical tips on recognizing, preventing and managing gastrointestinal and nutritional side effects The promise and peril of

Oral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes

Clinical trials suggest that Zepbound can lead to a weight reduction of 15-20%, depending on the dosage and patient adherence to lifestyle adjustments

Lakhani M, Kwan ATH, Mihalache A, et al

Palanca A, van Nes F, Pardo F, Ampudia Blasco FJ, Mathieu C (2022) Real-world evidence of efficacy and safety of SGLT2 inhibitors as adjunctive therapy in adults with type 1 diabetes: a European two-center experience

PMID: 30721960

In markets where there is state/PMI reimbursement of GLP-1 treatment for obesity (eg the US), retatrutide is likely to be reserved as a second-line GLP-1 for those who have failed to lose sufficient weight with a cheaper alternative (such as semaglutide or tirzepatide)