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But how, exactly, are they doing that?
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* BRET : Bioluminescence resonance energy transfer BSA : Bovine serum albumin CyOFP : Cyan-excitable orange fluorescent protein DERET : Diffusion-enhanced resonance energy transfer FCS : Fluorescence correlation spectroscopy FITC : Fluorescein isothiocyanate GFP : Green fluorescent protein GLP-1(R)(A) : Glucagon-like peptide-1 (receptor) (agonist) GUV : Giant unilameller vesicle MCD : Methyl--cyclodextrin Nb37 : Nanobody-37 POPC : 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine T2D : Type 2 diabetes TMR : Tetramethylrhodamine TR-FRET : Time-resolved Frster resonance energy transfer
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In the process, this review will also provide a physiological overview of the incretin system and how key components function in T2DM.
