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10.1677/JOE-06-0148

The sections that follow walk the science, the pipeline, the clinical readouts, the deal map, and the patent layer that sits underneath all of it

This magnitude of body weight reduction had not been reported to date in any other phase 2 or 3 trials testing weekly GLP-1RA or GLP-1R/GIPR dual agonists in patients living with T2DM, potentially due to the additional agonism of the glucagon receptor (Grunberger et al

American Enterprise Institute

For patients and clinicians, this was a novel mechanism a drug for diabetes that caused weight loss and had low hypo risk was almost unheard of at the time

showing MOTS-c functionally prevents metabolic disorders including insulin resistance and obesity, the main physiological functions include reducing insulin resistance, preventing obesity, improving muscle function, and promoting bone metabolism