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Youre standing at the Chipotle counter, maybe a little tired, a little hungry, and honestly just trying to make a decent food choice

Purpose of Review This review will summarize the most contemporary trials for glucagon-like peptide 1 receptor agonists (GLP1-RA) and sodium-glucose cotransporter 2 inhibitors (SGLT2-i) and present guidance on management and recommendations on adjunctive tapering of insulin in patients with insulin-dependent diabetes mellitus, which we term de-insulinization. Recent Findings GLP1-RA and SGLT2-i are the principal classes of diabetes medications evidencing cardiovascular benefit

As reported at the 2026 Crohns and Colitis Congress, GLP-1 RAs are potentially beneficial as an adjunct to Crohns disease management for patients with overweight or obesity.

While the world has focused on the battle between injectables and oral tablets, the "Mucosal Frontier" addresses the three biggest hurdles in peptide therapy: 1 Bioavailability: By utilizing a mucosal delivery platform, the drug avoids first-pass metabolism in the liver, potentially offering a more efficient way for the body to utilize the peptide compared to traditional oral versions

The use of branded ingredients allows private label partners to leverage established research narratives, ingredient storytelling, and clinical positioning strategies in their marketing materials

Discontinued treatment, low maintenance dosage led to reduced effectiveness of GLP-1 medications on body weight and blood sugar levels