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This study, together with a companion manuscript, shows that in mice, weight loss as a result of GIP receptor antagonism requires and potentiates functional GLP-1 receptor signalling in the brain, explaining how both GIP receptor agonists and antagonists trigger weight loss through different mechanisms.

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Semaglutide can cause temporary energy dips as your body adjusts to appetite suppression and metabolic changes

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This makes it an ideal option for weight loss in non-diabetics

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