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Many patients taking semaglutide (Ozempic, Wegovy, Rybelsus) experience constipation as a side effect, leading to questions about whether laxatives can be safely used alongside this medication

In the mentioned semaglutide dosing study, adverse events (side effects) occurred in 43.5% of placebo recipients (the so-called nocebo effect wherein people taking placebo still report side effects)

The 28.7% at 68 weeks in TRIUMPH-4 is observed in a specific population (obesity + knee OA)

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However, the benefit in reducing stroke events was not seen in the outcome studies of SGLT-2 inhibitors (260)

States were ranked based on total Medicaid spend on these GLP-1 drugs between 11/1/23 and 10/31/24