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Using the efficacy estimand (treatment-adherent analysis), the 36 mg dose achieved 12.4% average weight loss, equivalent to approximately 27.3 pounds

PMID 37796527

9 The semaglutide group exhibited significant improvements in symptoms and physical limitations, assessed using the Kansas City Cardiomyopathy Questionnaire Clinical Summary Score (KCCQ-CSS), with the change in KCCQ-CSS being the primary trial endpoint

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Some providers may prescribe off-label for specific metabolic conditions, but this remains controversial and is not covered by any standard insurance plan

For patients who value face-to-face care or prefer a more direct relationship with their provider, that local presence can make a meaningful difference