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During the second round of voting, 15 out of 16 questionnaires were returned

Predominantly gastrointestinal nausea, diarrhea, vomiting, constipation, and decreased appetite all dose-dependent and most common after a dose or an escalation

Cumulative incidence curves stratified by GLP-1 RA type were generated using time-to-onset data, excluding reports with implausible (onset 0 days) or missing event dates (Table S4)

For instance, given the potent anti-inflammatory properties of GLP-1 agonists, which can reduce hs-CRP levels by 2030% [28], future trials could explore whether patients with a high baseline inflammatory burden (elevated hs-CRP) derive a disproportionately larger cardiovascular benefit [95]

Orlistat increases urinary oxalate excretion, raising the risk of calcium oxalate kidney stones and, rarely, oxalate nephropathy it should be used with caution or avoided in people with CKD or a history of kidney stones