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Depression and obesity: Evidence of shared biological mechanisms

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In the subgroup analysis, although no significant differences were observed among the subgroups based on different baseline weight, control groups, and indications, significant weight regain was observed in each subgroup compared with the control group, that is, the weight regain after treatment discontinuation was consistent in obese patients with different characteristics

The mechanism of action includes several key effects: Stimulating insulin secretion from the pancreas in a glucose-dependent manner, helping to control blood sugar levels Slowing gastric emptying , which prolongs the feeling of fullness after meals Reducing appetite through effects on brain centres that regulate hunger Decreasing glucagon secretion , which helps prevent excessive glucose production by the liver By targeting these multiple pathways, GLP-1 medications can lead to significant weight loss when combined with lifestyle modifications

Careful attention to timing, severity, and symptom progression helps clinicians distinguish benign side effects from those requiring discontinuation or referral

Vomiting can be managed by staying well hydrated and having more frequent meals in smaller amounts