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Regulatory agencies may need to consider populationspecific monitoring recommendations as the use of GLP1RAs continues to expand

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1 Dual agonism of GIP and GLP-1 receptors is a promising new approach currently in clinical development for the treatment of diabetes, obesity, and associated complications [1] The incretin effect defines the main physiological role of GIP and GLP-1 GIP and GLP-1 increase insulin secretion following nutrient-induced secretion from the gut (incretin effect): There is a stronger insulin secretion response to oral compared to 'isoglycemic' intravenous glucose administration due to secretion and action of incretin hormones

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This work has included pharmacokinetic optimization, with steps to prevent peptide inactivation and to extend the pharmacodynamics to minimize the number of injections required for therapeutic effect

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