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Weight loss outcomes: The overall study population saw an average weight loss of 16.2% at 12 months and 17.2% at 24 months

Cremonini, E

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Patients needing more aggressive weight reduction (20%+ body weight loss) are likely better served by tirzepatide or future triple-agonist therapies like retatrutide that produce higher average weight loss

Both GLP-1 receptor agonists and metformin are commonly used to manage insulin resistance , but they work in different ways

After propensity-score matching, the two cohorts (26,784 in each cohort, mean age 51.3 years, 65.6% women, 16.1% Black, 66.5% White, 6.7% Hispanic) were balanced (Table 1)