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Acknowledgements We would like to express our gratitude to all the patients and their families, without whom this study would not have been possible

These include maintaining regular meal patterns despite reduced appetite, avoiding prolonged fasting, ensuring adequate sleep (79 hours nightly), and managing stress through relaxation techniques

This timing allows the medication to distribute properly in the subcutaneous space

Figure 1 Table 1 Basic characteristics of the eligible studies

When you flood them with a dose your body is not prepared for, the gastrointestinal system rebels

At a standard dose of 300 micrograms per day, a 5mg vial lasts approximately 16 days