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B6 accumulation and upper limits While vitamin B6 is water-soluble and excess amounts are excreted through urine, chronic high-dose supplementation can cause problems

These differences likely arise from our much larger dataset encompassing 28 RCTs, allowing for more accurate comparative estimates between treatments

Cochrans Q test and the I -squared statistic were used ( I 2 values of less than 25%, 50%, and more than 75% indicated low, moderate, and high heterogeneity, respectively (with caution)

4.6 SURPASS-6 trial: tirzepatide vs