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This demonstrates a cognitive regulation of satiation, in which a feed-forward mechanism increases satiation before the initiation of a meal, eventually leading to meal termination (Fig

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132, 134-136 It is, therefore, important to ensure that all people with diabetes undergoing elective surgery, and specifically those requiring general anaesthesia or deep sedation, undergo preoperative evaluation if they are on GLP-1 receptor therapy, as recommendations regarding the cessation of these drugs are inconsistent and lack a sound evidence base

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doi: 10.1038/oby.2008.357

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