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A proof-of-concept, open-label trial of weekly exenatide (2 mg, 48 weeks, 50 patients) showed an advantage in the unified multiple system atrophy rating scale (UMSARS, parts I and II combined score) at 48 weeks compared with best medically treated participants, but no difference in more objective secondary measures or biomarkers (neurofilament light chain [NfL], CSF -synuclein oligomers) (165)

Prescription is not guaranteed: Independent clinicians determine appropriateness based on individual health factors
The median duration of T2DM was 4.05 years (range 29 years)
ShedRx gave me the tools I needed to make sustainable changes. Interview with Semaglutide User #2: Johns Remarkable Transformation John, a 42-year-old accountant, had been overweight for most of his adult life

Some of the biggest rounds for startups vending GLP-1 drugs have been in the US, including Calibrates $100m in 2021 and Form Healths $38m in June this year
