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References 1.Abdelaal M, le Roux CW, Docherty NG

[DOI] [PubMed] [Google Scholar] 53

Finally, since endogenous GLP-1 is involved in the regulation of energy metabolism both in the periphery as well as in the brain, compounds acting as GLP-1R agonists can also normalize mitochondrial function, which also appears to be repeatedly disrupted in the depressive brain and thus possibly exacerbate neuroprotective effects, e.g

Three classic MAPK signaling pathways are extracellular signal-regulated kinase (ERK), p38 MAPK, and c-Jun N-terminal kinase (JNK)