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Beyond these metabolic benefits, accumulating evidence indicates that GLP-1RAs exert immunomodulatory effects, including suppression of pro-inflammatory cytokines, enhancement of regulatory T-cell function, and improvements in adipose tissue and gut-derived immune signaling

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In people living with obesity, research has shown that dopamine signalling in the striatum a key reward-processing area can become dysregulated, requiring ever-greater stimulation to generate the same sense of reward

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