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The worldwide health emergency of obesity is closely connected to how dietary fats are metabolized, whereas the process is significantly influenced by pancreatic lipase (PL), an enzyme critical for lipid hydrolysis into fatty acids

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Notably, DXA-based body composition analysis showed ~9293% of weight loss was derived from fat mass, suggesting relative preservation of lean mass a key limitation of many current weight-loss strategies

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However, the drugs alterations in gut motility may account for many of their commonly reported adverse effects including nausea, vomiting, early satiety, dyspepsia, and bowel habit changes

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