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These are frequently reported during dose titration periods and often decrease over time as the body adjusts

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When researchers used erythromycin (a prokinetic) to override the effects on stomach emptying, GLP-1's ability to lower glucose dropped [3]
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Journal of Research in Medical Sciences, 17 (12), 11611169

Once a healthy weight is reached, sustaining those lifestyle habits is key, because then the medication dose can be gradually reduced or you can take it intermittently as appropriate

These typically ease as the dose is gradually increased
