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Renal impairment GLP-1 RAs are generally safe in patients with CKD and have demonstrated nephroprotective effects in the FLOW trial, where semaglutide significantly reduced the composite renal endpoint (hospitalization for acute kidney injury, sustained 50% decline in estimated glomerular filtration rate (eGFR), end-stage kidney disease, or renal death) in patients with type 2 diabetes and CKD [15]

Factors like side effects, tolerability, cost, and individual goals (e.g., weight loss vs

What helps: Strength training 23x per week Prioritizing protein Not staying in a calorie deficit for too long 4

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The cost landscape is changing fast