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10.1016/j.jot.2023.02.003 Summary Keywords GLP-1, semaglutide, osteogenic differentiation, LRP5, signaling pathway Citation Tian Y, Liu H, Bao X and Li Y (2025) Semaglutide promotes the proliferation and osteogenic differentiation of bone-derived mesenchymal stem cells through activation of the Wnt/LRP5/-catenin signaling pathway

However, clinical trials so far have not shown clear benefit of GLP-1 RAs in HF

Furthermore, the clinical evidence, primarily derived from large-scale retrospective analyses, shows a promising signal for glaucoma prevention

may further increase to 14 mg if needed

Serious interactions are rare