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J Transl Med

For most medications, this is unlikely to create clinically significant changes

Otherwise, there must be some other change that a prescriber determines produces a significant difference for the individual patient, documented on the prescription

When to Worry: Red Flags That Need a Doctor Bottom line: Call your clinician the same day, or go to urgent care, if you experience blood in the stool, fever above 101F, signs of dehydration (dizziness, dark urine, dry mouth), severe abdominal pain, vomiting that prevents fluids for more than 12 hours, GI symptoms lasting more than 7 days without improvement, or sudden weight loss greater than 5% in a week

These effects can differ significantly from person to person

Routine follow-up discussion should address bowel changes that, while not severe, significantly impact quality of life or treatment adherence