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At approved weight-loss doses, caloric intake typically decreases in a consistent and measurable way

Retatrutide activates three receptor pathways (GLP-1, GIP, glucagon) compared to semaglutide's one (GLP-1)

GLP-1

While typically manageable, these effects can affect how well patients tolerate the drugs over time

et al., SGLT2-Inhibitor and Major Adverse Cardiovasc

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