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a classical experiment involving damaging a small part of the brain (In technical jargon, a bilateral Ventromedial hypothalamic lesion) caused rats to become morbidly obese (Pictured to the right)

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Mechanism of action: GLP-1 receptor agonists bind to GLP-1 receptors located throughout the body, particularly in pancreatic beta cells, the gastrointestinal tract, and the central nervous system

Obesity and insulin resistance can also affect other pathways, such as the insulin-like growth factor system