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Understanding cartilage protection in OA and injury: A spectrum of possibilities
The proposed direct vascular mechanisms, supported by preclinical and clinical data, include the following: Endothelial protection: GLP-1 receptor agonists promote nitric oxide production, vasodilation, and angiogenesis while inhibiting oxidative stress in vascular endothelial cells Plaque stabilization: Reduced matrix metalloproteinase activity prevents fibrous cap degradation

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Black, tarry stools: Another sign of GI bleeding further down the digestive tract

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