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Saffron at high doses has been associated with GI upset in some people, though the doses used in these studies werent flagged for safety concerns
10.1038/s41374-021-00640-3 [DOI] [PubMed] [Google Scholar] Liu L., Cui J., Zhao Y., Liu X., Chen L., Xia Y., et al
DPP-4 inhibitors, such as diprotin A, vildagliptin, and evogliptin tartrate, exhibit analgesic effects in rat models of carrageenan-induced sub-chronic inflammatory pain, as well as acute and tonic pain induced by CFA and formalin [36, 37]
At 24 months, there was a 68% reduction in papilledema risk
People with cardiovascular disease
