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Note: If you are currently taking any medication for thyroid issues, seizures, or blood thinning, you must consult a healthcare provider before starting Orlistat, as it is known to interfere with these specific drugs

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This causal link is supported by robust molecular evidence from models such as the db/db mouse, in which nuclear localization of ATF4 in -cells correlates with diminished insulinotropic responses and accelerated mass loss (Lee et al., 2023) ( Figure 1 , left)

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