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The intricacy of DPP4's function is accentuated by the range of bioactive compounds that serve as intricate agents in different bodily tissues, such as the immune and neuroendocrine systems

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In order to avoid hypoglycemia in patients on insulin a reduction in insulin dose may be considered, particularly in patients with good glycemic control
While most available studies emphasize systemic metabolic improvements, relatively few investigate direct vascular, immune-cell, and plaque-resident effects

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