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Effects and Duration of GLP-1 in the Body Even after the medication starts to leave your system, some effects may linger

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careful riskbenefit assessment is warranted Those with pre-existing gallbladder disease : Rapid weight loss can precipitate gallstone formation or worsen existing biliary conditions People with severe gastrointestinal disease, including gastroparesis : GLP-1 receptor agonists slow gastric emptying, which may worsen symptoms in those with pre-existing gastric motility disorders Older adults : Age-related changes in renal and hepatic function may affect drug metabolism and increase sensitivity to side effects

Genome Res 14 , 21622168 (2004)

Our resource on peptides for fat loss emphasizes that muscle preservation during rapid weight loss requires deliberate protein targeting of 0.8 to 1 gram per pound of lean body mass