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Sometimes, it goes away

Semaglutide typically produces measurable weight loss within 4 to 8 weeks of starting treatment, though individual timelines vary based on genetics, metabolism, and dosage progression

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Compared with liraglutide alone, the combined treatment decreased time to complete a stair climb test by 1.2 s [95% confidence interval 0.61.9] (corresponding to 8.6%) and improved peak oxygen consumption by 3.0 mL/min/kg fat-free mass [95% confidence interval 0.55.5]

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