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Patients appear gaunt not only due to volume loss but also resulting from changes in the facial skin where there is a loss of collagen, elastin, and essential nutrients

I was expecting to see more GI side effects with the higher dose, but it wasn't too much higher--70.8% at 7.2 mg vs 61.2% at 2.4 mg vs 42.8% with placebo, mostly mild an self-limited

The evidence suggests not.

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