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GLP-1Rs in the pancreas and brain have been shown to account for the respective improvements in glycemic control and body weight that are evident with liraglutide and semaglutide

Avoid excessive caffeine or alcohol, as they can cause dehydration

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These treatments are not routinely available for weight management alone and must meet specific eligibility requirements outlined in NICE guidance

"Amylin receptor agonists for obesity treatment: mechanisms and clinical applications." Journal of Clinical Endocrinology & Metabolism , 108(4), 892-904