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The diabetic mice were then randomly assigned to one of three groups: diabetes control (T2DM), semaglutide treatment (0.1 mg/kg, i.p., administered every other day) [28], and dapagliflozin treatment (1 mg/kg, p.o., administered daily) [25]

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3.1.2 Exenatide As the first GLP-1R agonist approved for T2DM, EX is a new class of compound and a synthetic product of exendin-4, which is a compound naturally derived from the Gila monster and has multiple hypoglycemic mechanisms: inhibiting of glucagon release from cells, slowing of gastric emptying, decreasing appetite and increasing glucose-dependent insulin secretion (46, 47)

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Clinical studies show that a large proportion of lost weight can be regained if medication stops and lifestyle habits are not in place to maintain the result