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Naturally occurring mutations in G protein-coupled receptors associated with obesity and type 2 diabetes mellitus

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Additionally, treatment with GLP-1RA and exendin-4 increased the expression of the calcitonin gene in the thyroids of normal (wild-type) mice

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Here, we identified a previously unrecognized role of hepatic TH action in modulating the GLP-1 and insulin secretion, which are important for the maintenance of systemic glucose homeostasis