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Description
Paired-end sequencing of the library was performed using the Illumina HiSeq platform (Illumina Inc., San Diego, CA, USA)

Predominantly gastrointestinal nausea, diarrhea, vomiting, constipation, and decreased appetite all dose-dependent and most common after a dose or an escalation
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The metabolic ligand adenosine diphosphate (ADP), which derives from the AC, acts on K + channels, increasing membrane potential following channel closure and reducing the repolarization stage [33]

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