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Conclusion Modulation of GLP-1R affects CSF production, which suggests that GLP-1R-mediated signalling may have the potential to control ICP in pathological conditions with disturbed CSF homeostasis.

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[3] Myostatin: a potential therapeutic target for metabolic syndrome

The greater weight loss seen with tirzepatide may be due to the additional activation of the GIP receptor, which appears to further enhance insulin sensitivity, reduce food intake, and promote fat breakdown